Faculty
Dr. Tu Lee Professor
Office Phone: +886-3-4227151#34204
E-mail: tulee@cc.ncu.edu.tw
Office: Room E237B, E...
detail
Education
Bachelor of Science in Chemistry, New York University, 1990 
Bachelor of Science in Chemical Engineering, The Cooper Union for the Advancement of Science and Art, 1990 
Master of Science in Chemical Engineering, The Cooper Union for the Advancement of Science and Art, 1993 
Doctor of Philosophy in Chemical Engineering, Princeton University, 2000

Experiences
•  Research investigator, Pharmaceuticals Research Institute, Bristol-Myers Squibb, 1999~2003•  Research investigator, Pharmaceuticals Research Institute, Bristol-Myers Squibb, 1999~2003
•  Assistant Professor, Department of Chemical and Materials Engineering, National Central University, 2004~2008
•  Associate Professor, Department of Chemical and Materials Engineering, National Central University, 2008~2011
•  Chair, Department of Chemical and Materials Engineering, National Central University, 2017~2020
•  Professor, Department of Chemical and Materials Engineering, National Central University, 2011~until now
•  Visiting Scholar at the Department of Pharmaceutical Sciences in St. John's University, NY, USA (June 2016 - September 2016)
•  Department Chair 8/2017 to 7/2020 in Department of Chemical and Materials Engineering of National Central University

Research Interests
Crystallization of Simple Organic Molecules, 
Pharmaceutical Engineering and Biomineralization

Research Background

        Our research group aims towards crystallization of simple organic molecules, pharmaceutical engineering and biomineralization under the umbrella of crystallization which is a bottom-up purification and fabrication method.  We place our focuses especially on the issues of value enhancement, large-scale manufacturing and product reproducibility for functional crystalline materials through the enabling platform of engineering parameters screening and under the inspirations from biology in (1) (1)Bio-mineralization，(2)Chiral Resolution，(3)Circular Economy，(4)Co-crystallization，(5)Hydrothermal process，(6)Polymorphism，(7)Reaction crystallization，(8)Salt formation，(9)Spherical crystallization, and(10) Wet Granulation.
Thesis Publications

1.   Aksay, I. A.; Chun, C. M.; Lee, T. Mechanisms of BaTiO3 formation by hydrothermal reactions. In Proc. The Second Int’l Conf: On Solvothermal Reactions; Committee of Solvothermal Technology Institute: Takamatsu, Kagawa, Japan, 1996; pp 35-41.
2.   Lahiri, J.; Xu, G.; Lee, T.; Dabbs, D. M.; Yao, N.; Aksay, I. A.; Groves, J. T. Biomimetic fabrication of material-the minimalist approach. SPIE Proc. 1996, 2716, 317-323.
3.   Lee, T.; Yao, N.; Aksay, I. A. Nanoscale patterning of barium titanate on block copolymers. Langmuir. 1997, 13(14), 3866-3870.
4.   Lee, T.; Yao, N.; Aksay, I. A. Nanoscale patterning of BaTiO3 on block copolymers. In Proc. Microscopy and Microanalysis; Bailey, G. W.; Dimlich, R. V. W.; Alexander, K. B.; McCarthy, J. J.; Pretlow, T. P., Eds.; Springer-Verlag: New York, NY, 1997; pp 423-24.
5.   Yao, N.; Trau, M.; Manne, S.; Nakagawa, N.; Lee, T.; Honma, I.; Aksay, I. A. Mesoscopic silica thin films via template-assisted self-assembly. In Microscopy and Microanalysis, Bailey, G. W.; Dimlich, R. V. W.; Alexander, K. B.; McCarthy, J. J.; Pretlow, T. P., Eds.; Springer-Verlag: New York, NY, 1997; pp 395-396.
6.   Luther, E. P.; Chun, C. M.; Lee, T.; Aksay, I. A. In situ processing of nanosize polymer/BaTiO3 dilelectric films. In Advances in Dielectric Ceramic Materials, Nair, K. M.; Bhalla, A. S., Eds.; The American Ceramic Society: Westerville, OH, 1998; pp 189-194.
7.   Yao, N.; Ku, A. Y.; Nakagawa, N.; Lee, T.; Saville, D. A.; Aksay, I. A. Disorder-order transition in mesoscopic silica thin films. Chem. Mater. 2000, 12(6), 1536-1548.
8.   Lee, T.; Aksay, I. A. Hierarchical structure-ferroelectricity relationships of barium titanate particles. Cryst. Growth Des. 2001, 1(5), 401-419.
9.   Lee, T.; Yao, N.; Imai, H.; Aksay, I. A. Barium titanate nanoparticles in block copolymer. Langmuir. 2001, 17(24), 7656-7663.
10.  Lee, T.; Lee, J. Drug-carrier screening on a chip. Pharm. Tech. 2003, 27(1), 40-48.
11.  Lee, T.; Lee, J. Particle attrition by particle-surface friction in dryers. Pharm. Tech. 2003, 27(5), 64-72.
12.  Yin, S. X.; Franchini, M.; Chen, J. L.; Hsieh, A.; Jen, S.; Lee, T.; Hussain, M.; Smith, R. Bioavailability enhancement of a COX-2 inhibitor, BMS-347070, from a nanocrystalline dispersion prepared by spray-drying. J. Pharm. Sci. 2005, 94(7), 1598-1607.
13.  Kim, S.; Lotz, B.; Lindrud, M.; Girard, K.; Moore, T.; Nagarajan, K.; Alvarez, M.; Lee, T.; Nikfar, F.; Davidovich, M.; Srivastava, S.; Kiang, S. Control of the particle properties of a drug substance by crystallization engineering and the effect on drug production formulation. Org. Process. Res. Dev. 2005, 9(6), 894-901.
14.  Lee, T.; Hung, S. T.; Kuo, C. S. A Bio-Inspired Approach: Polymorph Farming on a Chip. Pharm. Technol. 2006, 30(3), 82-94.
15.  Lee, T.; Kuo, C. S. Effects of initial average particle size on tableting: evaluating predictive tools for crystal engineers and formulators. Pharm. Technol. 2006, 30(3), 110-120.
16.  Lee, T.; Kuo, C. S.; Chen, Y. H. Solubility, polymorphism, crystallinity, and crystal habit of acetaminophen and ibuprofen by initial solvent screening. Pharm. Tech. 2006, 30(10), 72-92.
17.  Lee, T.; Hung, S. T.; Kuo, C. S. Polymorph farming of acetaminophen and sulfathiazole on a chip. Pharm. Res. 2006, 23(11), 2542-2555.
18.  Lee, T.; Kuo, C. S.; Chen, Y. H. Solubility, polymorphism, crystallinity and crystal habit of acetaminophen and ibuprofen Part I. Pharmaceutical Canada. 2007, 8(1), 15-17.
19.  陳映秀、洪士婷、李度，界面科學與化工應用專輯製藥業的同質異相篩選的技術與回顧，化工技術，第十五卷，第一期，第82-87頁(2007)。
20.  Lee, T.; Chen, Y. H.; Zhang, C. W. Solubility, polymorphism, crystallinity, crystal habit, and drying scheme of (R,S)-(±)-sodium ibuprofen dihydrate. Pharm. Tech. 2007, 31(6), 72-87.
21.  Lee, T.; Lin, M. S. Sublimation point depression of tris(8-hydroxyquinoline)aluminum (III) (Alq3) by crystal engineering. Cryst. Growth Des. 2007, 7(9), 1803-1810.
22.  Lee, T.; Lin, Y. S. Dimorphs of sucrose. Int. Sugar J. 2007, 109(1303), 440-445.
23.  Lee, T.; Hsu, F. B. A cross-performance relationship between Carr's index and dissolution rate constant: The study of acetaminophen batches. Drug Dev. Ind. Pharm. 2007, 33(11), 1273-1284.
24.  Lee, T.; Hung, S. T. Cocktail-solvent screening to enhance solubility, increase crystal yield, and induce polymorphs. Pharm. Tech. 2008, 32(1), 76-95.
25.  侯宏儒、謝翔宇、王業文、蘇彥成、張世佳、陳君達、陳正國、李度，熱分析與熱量計在藥物開發上之應用，化工技術，第八卷，第一八五期，第134-151頁(2008)。
26.  Lee, T.; Kuo, C. S.; Chen, Y. H. Solubility, polymorphism, crystallinity and crystal habit of acetaminophen and ibuprofen Part II. Pharmaceutical Canada. 2008, 8(3), 19-25.
27.  Lee, T.; Zhang, C. W. Dissolution enhancement by bio-inspired mesocrystals: The study of racemic (R,S)-(+/-)-sodium ibuprofen dihydrate. Pharm. Res. 2008, 25(7), 1563-1571.
28.  Lee, T.; Chen, Y. H.; Wang, Y. W. Effects of homochiral molecules of (S)-(+)-ibuprofen and (S)-(-)-sodium ibuprofen dihydrate on the crystallization kinetics of racemic (R,S)-(±)-sodium ibuprofen dihydrate. Cryst. Growth Des. 2008, 8(2), 415-426.
29.  Lee, T.; Hou, H. J.; Hsieh, H. Y.; Su, Y. C.; Wang, Y. W.; Hsu, F. B. The prediction of the dissolution rate constant by mixing rules: The study of acetaminophen batches. Drug Dev. Ind. Pharm. 2008, 34(5), 522-535.
30.  Lee, T.; Chang, S. C. Sublimation point depression of small-molecule semiconductors by sonocrystallization. Cryst. Growth Des. 2009, 9(6), 2674-2684.
31.  張世佳、陳君達、陳正國、彭鎮帆、林育琨、汪璞芸、李度，差之毫釐失之千里藥物研發過程中同質異構物的選擇指南，MD News 生技與醫療器材報導月刊，第一二五期，第41-45頁(2009)。
32.  Lee, T.; Wang, Y. W. Initial salt screening procedures for manufacturing ibuprofen. Drug Dev. Ind. Pharm. 2009, 35(5), 555-567.
33.  Lee, T.; Su, Y. C.; Hou, H. J.; Hsieh, H. Y. Initial Solvent Screening of carbamazepine, cimetidine, and phenylbutazone: Part 1 of 2. Pharm. Tech. 2009, 33(5), 62-72.
34.  Lee, T.; Su, Y. C.; Hou, H. J.; Hsieh, H. Y. Initial Solvent screening of carbamazepine, cimetidine, and phenylbutazone: Part 2 of 2. Pharm. Tech. 2009, 33(6), 54-61.
35.  Lee, T.; Chen, J. G. Biomimetic gallstone formation: crystallization of calcium carbonate by the evolving taurocholate-lecithin-cholesterol complex lipid system. Cryst. Growth Des. 2009, 9(8), 3737-3748.
36.  Lee, T.; Chang, G. D. Sucrose conformational polymorphism: A jigsaw puzzle with multiple routes to a unique solution. Cryst. Growth Des. 2009, 9(8), 3551-3561.
37.  Lee, T.; Wang, P. Y. Screening, manufacturing, photoluminescence, and molecular recognition of co-crystals: Cytosine with dicarboxylic acids. Cryst. Growth Des. 2010, 10(3), 1419-1434.
38.  Lee, T.; Peng, J. F. Photoluminescence and crystal structures of chiro-optical 1,1’-Bi-2-naphthol crystals and their inclusion compounds with dimethyl sulfoxide. Cryst. Growth Des. 2010, 10(8), 3547-3554.
39.  Lee, T.; Lin, Y. K. The origin of life and the crystallization of aspartic acid in water. Cryst. Growth Des. 2010, 10(4), 1652-1660.
40.  Lee, T.; Su, Y. C.; Hou, H. J.; Hsieh, H. Y. Spherical crystallization for lean solid-dose manufacturing (Part I) Pharm. Tech. 2010, 34(3), 72-75.
41.  Lee, T.; Su, Y. C.; Hou, H. J.; Hsieh, H. Y. Spherical crystallization for lean solid-dose manufacturing (Part II) Pharm. Tech. 2010, 34(4), 88-103.
42.  Lee, T.; Chang, G. D. Engineering processing properties of acetaminophen by cosolvent screening.Pharm. Tech. 2010, 34(8), 61-68.
43.  Lee, T.; Chang, S. C.; Peng, J. F. Tris(8-hydroxyquinoline)aluminum (III) (Alq3) nanowires templated from an eggshell membrane. Thin Solid Films 2010, 518(19), 5488-5493.
44.  蔡旻翰、陳政緯、林子淳、劉政鑫、林奕辰、李度，輾壓技術，特別企劃製藥技術，化工技術，第十八卷，第六期，第164-196頁(2010)。
45.  Lee, T.; Lin, Y. C. Mimicking the initial development of calcium urolithiasis by screening calcium oxalate and calcium phosphate phases in various urinelike solutions, time points, and pH values at 37oC. Cryst. Growth Des. 2011,11(7), 2973-2992.
46.  Lee, T.; Liu, Z. X.; Lee, H. L. A biomimetic nose by microcrystals and oriented films of luminescent porous metal-organic frameworks. Cryst. Growth Des. 2011, 11(9), 4146-4154.
47.  Lee, T.; Tsai, M. H.; Lee, H. L. Riboflavin chelated luminescent metal-organic framework: identified by liquid-assisted grinding for large-molecule sensing via chromaticity coordinates. Cryst. Growth Des. 2012, 12(6),3181-3190.
48.  Lee, T.; Chen, H. R.; Lin, H. Y.; Lee, H. L. Continuous co-crystallization as a separation technology: the study of 1:2 co-crystals of phenazine-vanillin. Cryst. Growth Des. 2012, 12(12), 5897-5907.
49.  林宏祐、蔡孟勳、李弘霖、薛喻仁、陳鑫榮、蔡雅鈞、邱鈺秀、謝宥晟、李度，結晶工程在綠色科技上的應用，化工技術，第二十卷，第十二期，第78-89頁(2012)。
50.  Cheng, S. L.; Lin, Y. H.; Lee, S. W.; Lee, T.; Chen, H.; Hu, J. C.; Chen, L. T. Fabrication of size-tunable, periodic Si nanohole arrays by plasma modified nanosphere lithography an anisotropic wet etching. Appl. Surf. Sci. 2012, 263, 430-435.
51.  Cheng, S. L.; Hsu, T. L.; Lee, T.; Lee, S. W.; Hu, J. C.; Chen, L. T. Characterization and kinetic investigation of electroless deposition of pure cobalt thin films on silicon substrates. Appl. Surf. Sci. 2013, 264, 732-736.
52.  Lee, T.; Lee, H. L.; Tsai, M. H.; Cheng, S. L.; Lee, S. W.; Hu, J. C.; Chen, L. T. A biomimetic tongue by photoluminescent metal-organic frameworks. Biosens. Bioelectron. 2013, 43, 56-62.
53.  Lee, T.; Chen, J. W.; Lee, H. L.; Lin, T. Y.; Tsai, Y. C.; Cheng, S.L.; Lee, S. W.; Hu, J. C.; Chen, L. T. Stabilization and spheroidization of ammonium nitrate: co-crystallization with crown ethers and spherical crystallization by solvent screening. Chem. Eng. J. 2013, 225(1), 809-817.
54.  Lee, T.; Lin, Y. K.; Tsai, Y. C.; Lee, H. L. Propagation of biochirality: crossovers and nonclassical crystallization kinetics of aspartic acid in water. Chirality 2013, 25(11), 768-779.
55.  Chang, H. T.; Wu, B. L.; Lee, T.; Lee, S. W. Uniform SiGe/Si quantum well nanorod and nanodot arrays fabricated using nanosphere lithography. Nanoscale Res. Lett. 2013, 8(1), 349.
56.  Lee, T.; Lin, H. Y.; Lee, H. L. Engineering reaction and crystallization and the impact on filtration, drying, and dissolution behaviors: the study of acetaminophen (paracetamol) by in-process controls. Org. Process Res. Dev. 2013, 17(9), 1168-1178.
57.  Lee, T.; Chiu, Y. H.; Lee, H. L. Thermal properties and structural characterizations of new types of phase change material: anhydrous and hydrated palmitic acid/camphene solid dispersions. Thermochim. Acta. 2014, 575, 81-89.
58.  Haung, S. H.; Twan, S. C.; Cheng, S. L.; Lee, T.; Hu, J. C.; Chen, L. T.; Lee, S. W. Influence of Al addition on phase transformation and thermal stability of nickel silicides on Si(0 0 1). J. Alloy. Compd. 2014, 586, S362-S367.
59.  Lee, H. L.; Lin, H. Y.; Lee, T. Large-scale crystallization of a pure metastable polymorph by reaction coupling. Org. Process Res. Dev. 2014, 18(4), 539-545.
60.  Lee, T.; Lee, Y.; Lee, H. L.; Syue, Y. R.; Chiu, Y. H.; Liou, J. Y.; Sun, Y. S. Bio-inspired phase change materials designed for high specific heat of solid phase. Thermochim. Acta. 2014, 591, 61-67.
61.  Lin, P. Y.; Lee, H. L.; Chen, C. W.; Lee, T. Effects of baffle configuration and tank size on spherical agglomerates of dimethyl fumarate in a common stirred tank. Int. J. Pharm. 2015, 495(2), 886-894.
62.  Lee, H. L.; Lee, T. Direct co-crystal assembly from synthesis to cocrystallization. CrystEngComm. 2015, 17(47), 9002-9006.
63.  Lee, T.; Lin, T. Y.; Lee, H. L.; Chang, Y. H.; Tsai, Y. C. Biomimetic taste receptors with chiral recognition by photoluminescent metal–organic frameworks chelated with polyaniline helices. Chem. Eur. J. 2016, 22(4), 1406-1414.
64.  Chih, M. H.; Lee, H. L.; Lee, T. The culprit of gout: triggering factors and formation of monosodium urate monohydrate. CrystEngComm. 2016, 18(2), 290-297.
65.  Lee, T.; Tsai, Y. C.; Lee, H. L.; Chang, Y. H.; Lin, T. Y. Metal-organic framework engineering: Directed assembly from molecules to spherical agglomerates. J. Taiwan Inst. Chem. Eng. 2016, 62, 10-20.
66.  李度、李弘霖、李之穎，新世紀的化學工程：化學工程在製藥過程中所扮演之角色及其發展，台灣化學教育，第十五期 (2016.9) (http://chemed.chemistry.org.tw/?p=20808)。
67.  Lee, T.; Chang, Y. H.; Lee, H. L. Crystallization process development of metal-organic frameworks by linking secondary building units, lattice nucleation and luminescence: The insight into reproducibility. CrystEngComm 2017, 19(3), 426-441. (Back Cover Artwork)
68.  Wang, C. L.; Yeh, K. L.; Chen, C. W.; Lee, Y.; Lee, H. L; Lee, T. A quick-fix design of phase change material by particle blending and spherical agglomeration. Appl. Energy 2017, 191, 239-250.
69.  Lee, H. L.; Vasoya, J. M.; Marilia de Lima Cirqueira; Yeh, K. L.; Lee, T.; Serajuddin, A. T. M. Continuous preparation of 1:1 haloperidol–maleic acid salt by a novel solvent-free method using a twin screw melt extruder. Mol. Pharmaceutics 2017, 14(4), 1278-1291.
70.  Chen, C. W.; Lee, T. Round granules of dimethyl fumarate by three-in-one intensified process of reaction, crystallization, and spherical agglomeration in a common stirred tank. Org. Process Res. Dev. 2017, 21(9), 1326-1339.
71.  Yeh, K. L.; Lee, T. Intensified crystallization processes for 1:1 drug-drug co-crystals of sulfathiazole-theophylline, and sulfathiazole-sulfanilamide. Cryst. Growth Des. 2018, 18(3), 1339-1349.
72.  麥進成、陳峙瑋、葉冠麟、李度，原料藥廠的角色：活性藥物成分的製程開發，化工會刊，第六十五卷，第一期，第4-7頁(2018)。
73. Chen, T.-H.; Yeh, K. L.; Chen, C. W.; Lee, H. L.; Hsu, Y. C.; Lee, T.  Mixing effect on stoichiometric diversity in benzoic acid-sodium benzoate cocrystals. Cryst. Growth Des. 2019, 19(3), 1576-1583.
74. Damayanti, J. D.; Pratama, D. E; Lee, T.  Green technology for salt formation: slurry reactive crystallization studies for papaverine HCl and 1:1 haloperidol–maleic acid salt. Cryst. Growth Des. 2019, 19(5), 2881-2891.
75. Lee, T. Yeh, K. L.; You, J. X; Fan, Y. C.; Cheng, Y. S.; Pratama, D. E.  Reproducible crystallization of sodium dodecyl sulfate·1/8 hydrate by evaporation, antisolvent addition, and cooling. ACS Omega 2020, 5(2), 1068-1079.
76. Li, Z.-H. ; Yu, T.; Lee, T.; Kim, W.-S.  Cocrystallization of caffeine–maleic acid in a batchelor vortex flow. Cryst. Growth Des. 2020, 20(3), 1618-1627.
77. Pratama, D. E.; Hsieh, W.-C.; Elmaamoun, A.; Lee, H. L.; Lee, T.  Recovery of active pharmaceutical ingredients from unused solid dosage-form drugs. ACS Omega 2020, 5(45), 29147-29157.
78. Lepeltier, E.; Levet, V.; Lee, T.; Mignet, N.; Shen, J.; Fenniri, H.; Corvis, Y.  Editorial: Supramolecular Nanomaterials for Engineering, Drug Delivery, and Medical Applications. Front Chem. 2020, 8, 626468. (DOI:10.3389/fchem.2020.626468)
79. Lee, H. L.; Chiu, C. W.; Lee, T.  Engineering terephthalic acid product from recycling of PET bottles waste for downstream operations. Chem. Eng. J. Adv. 2021, 5, 100079. “(linked to UN SDG 12: Ensure sustainable consumption and production patterns by Elsevier)” 
80. Yeh, K. L.; Lee, T. Selective formation of form II paracetamol through the assistance of paracetamol co-crystal as templates in a solution. CrystEngComm, 2021, 23(22), 3940-3945. (Back Cover Artwork)
81. Lini, F. Z.; Pratama, D. E.; Lee, T. Co-crystallization kinetics of 2:1 benzoic acid-sodium benzoate co-crystal: the effect of templating molecules in a solution. Crystals, 2021, 11(7), 812.
82. Chen, C. W.; Lee, H. L.; Yeh, K. L.; Lee, T. Effects of Scale-Up and Impeller Types on Spherical Agglomeration of Dimethyl Fumarate. Ind. Eng. Chem. Res, 2021,60(30), 11555-11567.
83. Lee, H. L.; Cheng, Y. S.; Yeh, K. L.; Lee, T. A Novel Hydrate Form of Sodium Dodecyl Sulfate and Its Crystallization Process. ACS Omega, 2021, 6(24), 15770-15781.
84. Pratama, D. E.; Hsieh, W. C.; Lin, K. Y.; Chen, Y. Y.; Lin, C. C.; Hu,Y. F.; Lee, T. Unconventional Separation of Arsenic Trioxide from Unused Aqueous Chemotherapeutic Agents by Direct Evaporative Crystallization. Sep Sci Technol, 2021, 56(15), 2634-2647.
85. Hsueh, J. C.; Yeh, K. L.; Lee, H. L.; Lee, T. Strategy for Polymorphic Control by Enzymatic Reaction and Antisolvent Crystallization: Effect of Aminoacylase on Metastable β-Glycine Formation. React. Chem. Eng, 2021, 6, 2292-2305.  (Back Cover Artwork) 
86. Pratama, D. E.; Yang, C. L.; Chen, Y. Y.; Lin, C. C.; Hu, Y. F.; Lee, T. Quick-fix Agarose Beads Impregnated with Hydrous Ferric Oxide for As(Ⅲ) Species Removal from Pharmaceutical Wastewater. Sep Sci Technol, 2022, 57(7), 1013-1029. 
87. Tseng, J. D.; Lee, H. L.; Yeh, K. L.; Lee, T. Recyclable Positive Azeotropes for the Purification of Curcumin with Optimum Purity and Solvent Capacity. Chem Eng Res Des, 2022, 200-211.
88. Yeh, K. L.; Lee, H. L.; Lee, T. Crystallization of Form II Paracetamol with the Assistance of Carboxylic Acids toward Batch and Continuous Processes. Pharmaceutics. 2022, 14(5),1099.
89. Yang, C. L.; Lee, H. L.; Lee, T. Saving Energy Upon Water Removal in Drying by Making the α-Polymorph of L-Glutamic Acid. Sep. Sci. Technol., 2022, 57(12), 1948-1965.
90.  Lee, H. L.; Yang, C. L.; Lee, T. Shaping Particle Size Distribution of a Metastable Polymorph in Additive-assisted Reactive Crystallization by the Taguchi Method. Cryst. Eng. Comm., 2022,  24, 7176-7192.
91. Tseng, Z. H.; Lee, H. L.; Wu, S. Y.; Yeh, K. L.; Lee, T. Development of Sustainable Reaction and Separation Processes for Amantadine and Amantadine Hydrochloride. Chem. Eng. Res. Des., 2022, 188, 393-405.
92. Lee, H. L.; Hung, Y. L.; Amin, A.; Pratama, D. E.; Lee, T. Green and Strategic Approach for Chiral Resolution by Diastereomeric Salt Formation: The Study of Racemic Ibuprofen. Ind. Eng. Chem. Res., 2023, 62, 1946−1957.
93. Pratama, D. E.; Lee, T. Recycling of Resolving Agent and Solvent by Water-based Reactions and Phase Diagrams: Chiral Resolution Study of Racemic Ibuprofen. Chem. Eng. Res. Des., 2023, 192, 12-27.
94. Lee, H. L.; Yang, C. L.; Lee, T. Correction: Shaping Particle Size Distribution of a Metastable Polymorph in Additive-Assisted Reactive Crystallization by the Taguchi Method. Cryst. Eng. Comm., 2023, 25, 692-692.
95. Ma, P.; Toussaint, B.; Roberti, E. A.; Scornet, N.; Santos Silva, A.; Castillo Henríquez, L.; Cadasse, M.; Négrier, P.; Massip, S.; Dufat, H.; Hammad, K.; Baraldi, C.; Gamberini, M. C.; Richard, C.; Veesler, S.; Espeau, P.; Lee, T.; Corvis, Y. New Lidocaine-Based Pharmaceutical Cocrystals: Preparation, Characterization, and Influence of the Racemic vs. Enantiopure Coformer on the Physico-Chemical Properties. Pharmaceutics, 2023, 15(4), 1102.

Service

•   2021-2023 Taiwan Institute of Chemical Engineers Student Affairs Committee, Chairperson
•   2020-2023 Journal of the Taiwan Institute of Chemical Engineers, Associate Editor
•   Asian Crystallization Technology Society, Scientific Committee
•   2023 Asian Crystallization Technology symposium , Conference Chair and Steering / Organizing Committee Member
•   2024 The 15th International Workshop on Crystal Growth of Organic Materials (CGOM15), Steering / Organizing Committee Member


Invited presentations
•  Crystal Engineering of Acetaminophen by Initial Solvent Screening, Reaction Crystallization and Reaction Coupling. Workshop on Functional Crystallization Technology. (Jeju Island, Korea, 2018/02/07) 
•  Achieving Structural Purity of Crystalline Solids Reproducibly by Solvent-Based Industrial Crystallization in a Common Stirred Tank. Crystallization Seminar in Autumn 2019 (Sapporo, Japan, 2019/09/26)
•  Recovery of Chemotherapeutic Agent, Painkillers, and Antibiotic Drug from Unused Pharmaceutical Products by Crystallization. 2020TwIChE (國立清華大學，2020/10/24)
•  Separation Studies of Terephthalic Acid and L-Glutamic Acid for Chemical/Material Development. 2021TwIChE (高雄展覽館，2022/01/07)
•  Advancements in Pharmaceutical Technologies Drug Substance & Drug Product, Subject: Orchestration of API Polymorphism. 2022 CMC Supply Alliance and Bio-Industry Academy (On-Line，2/17~2/18)
•  Towards Sustainable Process and Product Development by Solution Crystallization. 2022TwIChE (淡江大學守謙國際會議中心，2022/12/03)

Awards
•  2009～2023  National Central University outstanding research award
•  2014  National Central University excellent senior teacher award
•  2012～2014  National Central University merit patent award
•  2014  Symposium on transport phenomena and applications outstanding research award
•  2013  National Central University teaching excellent teacher award
•  2013  Symposium on transport phenomena and applications outstanding research award
•  2012  National Central University outstanding research award
•  2010  National Central University excellent service award
•  2010  LCY chemical corporation excellent professor award
•  2009  National Central University teaching excellent teacher award
•  2007  National Central University outstanding research award
•  2007  National Central University research excellent teacher award
•  2006  National Central University service excellent teacher award
Patent
•  Method of fabricating mesocrystals of organic and organo-metallic compounds (03/14/2008), US 8134025 B2
•   Co-crystal compound of optical devices (05/11/2010), US 8653267 B2
•  有機光電材料奈米線之製備方法 (07/21/2010), I345589 (中華民國)
•  Co-crystal compound, method for preparing the same and oxidant of gas generator propellant (01/20/2012), US 8642789 B2
•  有機及有機金屬化合物製備介晶質之方法 (03/21/2012), I360434 (中華民國)
•  布洛芬胺鹽及其合成方法 (05/21/2012), I364413 (中華民國)
•  Method of obtaining conformational polymorph of sucrose (06/19/2012), US 8202987 B2
•  Optical device having solvate and manufacturing method thereof (09/11/2012), US 8263970 B2
•  Sucrose of new conformational polymorphs and manufacturing method thereof (09/25/2012), US 8273873 B2
•  蔗糖之同質異構形構製備方法 (10/21/2013), I412595 (中華民國)
•  建立氣體分子資料庫之方法 (11/01/2014), I458981 (中華民國)
•  Polymorph, polymorph screening system, and polymorph preparing and screening method (10/21/2014), US 8865093 B2

Industrial/Academic, Collaboration, and Internships

• Industrial
(1) LCY CHEMICAL CORP.,  serve consultant (2014/08)
(2) Pharmadax Inc.,  serve consultant (2012~2014)
(3) SyneuRx International (Taiwan) Corp.,  serve consultant (2015/07～2015/11)
(4) SYNGEN BIOTECH CO., LTD.,  serve consultant (2013/09)
• Academic

Subject

Requester

Date

藥物循環經濟：使用溶劑萃取和再結晶從各種藥物中回收活性藥物成分

TTY Biopharm Company Limited

108/12/01～109/11/30

HEPES粉粒體結晶參數最佳化

Hopax

106/08/01～107/01/31

Polymorphs Screening of Pharmaceuticals: The Case Study of Ribociclib Succinate

CHUNGHWA CHEMICAL SYNTHESIS & BIOTECH CO., LTD.

106/06/01～109/05/31

Polymorphism Screening od Pharmaceutical Co-crystal: The Case Study of Valsartan/Sacubitril

CHUNGHWA CHEMICAL SYNTHESIS & BIOTECH CO., LTD.

105/02/01～106/01/31
Photoluminescence Spectroscopies of MOF-74 and Y4I1 series Industrial Technology Research Institute 103

• TASS2022 Asia Sustainable Supply + Circular Economy Exhibition, booth display (Dhanang Edy Pratama, Chia-Ling, Yang) Business Today Issue 1253-Ministry of Economic Affairs Bureau of Industry Advertisement page133 (12/25/2020)
•   Taipei Times： US FDA greenlights TTY Biopharm's leukemia drug (2021/10/19)(https://www.taipeitimes.com/News/biz/archives/2021/10/19/2003766347)
•   2023-2024 France-Taiwan (ORCHID) Prograｍ：Theranostic immuno-Nanoparticles engineering and evaluation for Triple Negative Breast Cancer Treatments
• Internships

Company

Date

Sunny Pharmtech Inc.

2019/02~2019/06

ScinoPharm Taiwan

2015/07~2016/01

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